download ebook NMR SPECTROSCOPY IN DRUG DEVELOPMENT AND ANALYSIS .epub.mobi.pdf
von: Ulrike Holzgrabe,Iwona Wawer,Bernd Diehl
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis.
This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging.
In short, this book covers all aspects of drug analysis.
Auf unserer Website enthält die besten Bücher und Hörbücher, die Sie kostenlos herunterladen können. Unterstützte Geräte: Tolino, Android, IOS, Kobo, Pocketbook,Kindle und andere.Entdecken Sie beste Bücher!
Tags:
kostenlos herunterladen Voll Buch NMR Spectroscopy in Drug Development and Analysis
download ebook NMR Spectroscopy in Drug Development and Analysis
download buch NMR Spectroscopy in Drug Development and Analysis für Android
herunterladen ebook NMR Spectroscopy in Drug Development and Analysis für Booken
download ebook NMR Spectroscopy in Drug Development and Analysis kostenlos herunterladen ebook NMR Spectroscopy in Drug Development and Analysis kostenlos
gratis download buch NMR Spectroscopy in Drug Development and Analysis
kostenlos download bücher
gratis herunterladen das Buch auf Deutsch gratis download ebook NMR Spectroscopy in Drug Development and Analysis pdf
downloadNMR Spectroscopy in Drug Development and Analysis epub auf deutsch
kostenlos download ebook NMR Spectroscopy in Drug Development and Analysis pdf
kostenloslesen online NMR Spectroscopy in Drug Development and Analysis
herunterladen audiobook NMR Spectroscopy in Drug Development and Analysis
gratis herunterladen hörbuch NMR Spectroscopy in Drug Development and Analysis
download hörbuch NMR Spectroscopy in Drug Development and Analysis auf deutsch
download hörbuch NMR Spectroscopy in Drug Development and Analysis ogg
gratis download ebook NMR Spectroscopy in Drug Development and Analysis
herunterladen ebook NMR Spectroscopy in Drug Development and Analysis pdf
mp3
ogg
audio
